| Rank | Player (age), + - HOFer, Bold - Active | Yds | Years | Teams |
|---|---|---|---|---|
| 1. | Edgerrin James (30) | 11,991 | 1999-2008 | 2TM |
| 2. | LaDainian Tomlinson (29) | 11,444 | 2001-2008 | sdg |
| 3. | Fred Taylor (32) | 11,218 | 1998-2008 | jax |
| 4. | Warrick Dunn (33) | 10,821 | 1997-2008 | 2TM |
| 5. | Jamal Lewis (29) | 9,898 | 2000-2008 | 2TM |
| 6. | Shaun Alexander (31) | 9,453 | 2000-2008 | 2TM |
| 7. | Ahman Green (31) | 9,045 | 1998-2008 | 3TM |
| 8. | Clinton Portis (27) | 8,943 | 2002-2008 | 2TM |
| 9. | Ricky Williams (31) | 7,624 | 1999-2008 | 2TM |
| 10. | Thomas Jones (30) | 7,591 | 2000-2008 | 4TM |
| 11. | Deuce McAllister (30) | 5,995 | 2001-2008 | nor |
| 12. | Rudi Johnson (29) | 5,975 | 2001-2008 | 2TM |
| 13. | Michael Pittman (33) | 5,627 | 1998-2008 | 3TM |
| 14. | Brian Westbrook (29) | 5,442 | 2002-2008 | phi |
| 15. | Larry Johnson (29) | 5,421 | 2003-2008 | kan |
| 16. | Willis McGahee (27) | 5,061 | 2004-2008 | 2TM |
| 17. | Steven Jackson (25) | 4,868 | 2004-2008 | ram |
| 18. | Willie Parker (28) | 4,770 | 2004-2008 | pit |
| 19. | Frank Gore (25) | 4,331 | 2005-2008 | sfo |
| 20. | Julius Jones (27) | 4,158 | 2004-2008 | 2TM |
| 21. | Chester Taylor (29) | 3,952 | 2002-2008 | 2TM |
| 22. | Michael Bennett (30) | 3,627 | 2001-2008 | 4TM |
| 23. | Reuben Droughns (30) | 3,602 | 2001-2008 | 4TM |
| 24. | LaMont Jordan (30) | 3,391 | 2001-2008 | 3TM |
| 25. | DeShaun Foster (28) | 3,379 | 2003-2008 | 2TM |
| 26. | Ronnie Brown (27) | 3,207 | 2005-2008 | mia |
| 27. | Kevin Jones (26) | 3,176 | 2004-2008 | 2TM |
| 28. | Kevin Faulk (32) | 3,108 | 1999-2008 | nwe |
| 29. | Donovan McNabb (32) | 3,081 | 1999-2008 | phi |
| 30. | Marion Barber (25) | 3,037 | 2005-2008 | dal |
| 31. | Dominic Rhodes (29) | 2,970 | 2001-2008 | 2TM |
| 32. | Ladell Betts (29) | 2,927 | 2002-2008 | was |
| 33. | T.J. Duckett (27) | 2,779 | 2002-2008 | 4TM |
| 34. | Joseph Addai (25) | 2,667 | 2006-2008 | clt |
| 35. | Justin Fargas (28) | 2,654 | 2003-2008 | rai |
| 36. | Adrian Peterson (23) | 2,652 | 2007-2008 | min |
| 37. | Tatum Bell (27) | 2,572 | 2004-2008 | 2TM |
| 38. | Daunte Culpepper (31) | 2,554 | 1999-2008 | 4TM |
| 39. | Brandon Jacobs (26) | 2,481 | 2005-2008 | nyg |
| 40. | Michael Turner (26) | 2,465 | 2004-2008 | 2TM |
| 41. | Maurice Morris (29) | 2,326 | 2002-2008 | sea |
| 42. | Maurice Jones-Drew (23) | 2,261 | 2006-2008 | jax |
| 43. | Sammy Morris (31) | 2,254 | 2000-2008 | 3TM |
| 44. | Cadillac Williams (26) | 2,231 | 2005-2008 | tam |
| 45. | DeAngelo Williams (25) | 2,173 | 2006-2008 | car |
| 46. | Jeff Garcia (38) | 2,081 | 1999-2008 | 5TM |
| 47. | Correll Buckhalter (30) | 2,035 | 2001-2008 | phi |
| 48. | Marshawn Lynch (22) | 1,959 | 2007-2008 | buf |
| 49. | LenDale White (24) | 1,929 | 2006-2008 | oti |
| 50. | Cedric Benson (26) | 1,928 | 2005-2008 | 2TM |